Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC6120981 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Sun Li L Rautela Jai J Delconte Rebecca B RB Souza-Fonseca-Guimaraes Fernando F Carrington Emma M EM Schenk Robyn L RL Herold Marco J MJ Huntington Nicholas D ND Lew Andrew M AM Xu Yuekang Y Zhan Yifan Y
Frontiers in immunology 20180828
GM-CSF promotes myeloid differentiation of cultured bone marrow cells into cells of the granulocytic and monocytic lineage; the latter can further differentiate into monocytes/macrophages and dendritic cells. How GM-CSF selects for these different myeloid fates is unresolved. GM-CSF levels can change either iatrogenically (e.g., augmenting leukopoiesis after radiotherapy) or naturally (e.g., during infection or inflammation) resulting in different immunological outcomes. Therefore, we asked whet ...[more]