ERK Signaling Controls Innate-like CD8⁺ T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors.

ABSTRACT: In mouse thymocyte development, signaling by the TCR through the ERK pathway is required for positive selection of conventional naive T cells. The Ets transcription factor ELK4 (SAP-1), an ERK-regulated cofactor of the SRF transcription factor, plays an important role in positive selection by activating immediate-early genes such as the Egr transcription factor family. The role of ELK4-SRF signaling in development of other T cell types dependent on ERK signaling has been unclear. In this article, we show that ELK4, and its close relative ELK1, act cell autonomously in the thymus to control the generation of innate-like αβ CD8⁺ T cells with memory-like characteristics. Mice lacking ELK4 and ELK1 develop increased numbers of innate-like αβ CD8⁺ T cells, which populate t

SUBMITTER: Maurice D 

PROVIDER: S-EPMC6121213 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature