A Nationwide Registry-Based Study on Mortality Due to Rare Congenital Anomalies.

ABSTRACT: This study aimed to analyse population-based mortality attributed to rare congenital anomalies (CAs) and assess the associated time trends and geographical differences in Spain. Data on CA-related deaths were sourced from annual mortality databases kept by the National Statistics Institute of Spain (1999⁻2013). Based on the ICD-10, only CAs corresponding to rare diseases definition were included in this study. Annual age-adjusted mortality rates were calculated and time trends were evaluated by joinpoint regression analysis. Geographical differences were assessed using standardised mortality ratios and cluster detection. A total of 13,660 rare-CA-related deaths (53.4% males) were identified in the study period. Annual age-adjusted mortality rates decreased by an average of -5.2% (-5.5% mal

SUBMITTER: Alonso-Ferreira V 

PROVIDER: S-EPMC6121521 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature