Modulation of Gene Expression in Liver of Hibernating Asiatic Toads (Bufo gargarizans).

ABSTRACT: Hibernation is an effective energy conservation strategy that has been widely adopted by animals to cope with unpredictable environmental conditions. The liver, in particular, plays an important role in adaptive metabolic adjustment during hibernation. Mammalian studies have revealed that many genes involved in metabolism are differentially expressed during the hibernation period. However, the differentiation in global gene expression between active and torpid states in amphibians remains largely unknown. We analyzed gene expression in the liver of active and torpid Asiatic toads (Bufo gargarizans) using RNA-sequencing. In addition, we evaluated the differential expression of genes between females and males. A total of 1399 genes were identified as differentially expressed between a

SUBMITTER: Jin L 

PROVIDER: S-EPMC6121651 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature