The Therapeutic Strategy of HDAC6 Inhibitors in Lymphoproliferative Disease.

ABSTRACT: Histone deacetylases (HDACs) are master regulators of chromatin remodeling, acting as epigenetic regulators of gene expression. In the last decade, inhibition of HDACs has become a target for specific epigenetic modifications related to cancer development. Overexpression of HDAC has been observed in several hematologic malignancies. Therefore, the observation that HDACs might play a role in various hematologic malignancies has brought to the development of HDAC inhibitors as potential antitumor agents. Recently, the class IIb, HDAC6, has emerged as one potential selective HDACi. This isoenzyme represents an important pharmacological target for selective inhibition. Its selectivity may reduce the toxicity related to the off-target effects of pan-HDAC inhibitors. HDAC6 has also been studied

SUBMITTER: Cosenza M 

PROVIDER: S-EPMC6121661 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature