Chloride Content of Fluids Used for Large-Volume Resuscitation Is Associated With Reduced Survival.

ABSTRACT:

Objective

We sought to investigate if the chloride content of fluids used in resuscitation was associated with short- and long-term outcomes.

Design

We identified patients who received large-volume fluid resuscitation, defined as greater than 60 mL/kg over a 24-hour period. Chloride load was determined for each patient based on the chloride ion concentration of the fluids they received during large-volume fluid resuscitation multiplied by the volume of fluids. We compared the development of hyperchloremic acidosis, acute kidney injury, and survival among those with higher and lower chloride loads.

Setting

University Medical Center.

Patients

Patients admitted to ICUs from 2000 to 2008.

Interventions

None.

Measurements and main results

Among 4,710 p

SUBMITTER: Sen A 

PROVIDER: S-EPMC6121711 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature