Large-effect mutations generate trade-off between predatory and locomotor ability during arms race coevolution with deadly prey.

ABSTRACT: Adaptive evolution in response to one selective challenge may disrupt other important aspects of performance. Such evolutionary trade-offs are predicted to arise in the process of local adaptation, but it is unclear if these phenotypic compromises result from the antagonistic effects of simple amino acid substitutions. We tested for trade-offs associated with beneficial mutations that confer tetrodotoxin (TTX) resistance in the voltage-gated sodium channel (Na_V1.4) in skeletal muscle of the common garter snake (Thamnophis sirtalis). Separate lineages in California and the Pacific Northwest independently evolved TTX-resistant changes to the pore of Na_V1.4 as a result of arms race coevolution with toxic prey, newts of the genus Taricha. Snakes from the Cal

SUBMITTER: Hague MTJ 

PROVIDER: S-EPMC6121790 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature