Racial differences in in vivo adipose lipid kinetics in humans.

ABSTRACT: The storage of lipids in the form of triglycerides (TGs) and the de novo synthesis (lipogenesis) of fatty acids from nonlipid precursors [de novo lipogenesis (DNL)] are important functions of adipose tissue (AT) that influence whole-body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kinetics in humans. Fifty-two women with obesity (27 African-American and 25 Caucasian; 29.7 ± 5.5 years; BMI 32.2 ± 2.8 kg/m²; 44.3 ± 4.0% body fat) were enrolled in the study. In vivo synthesis (or replacement) of TGs (f_TG) as well as the synthesis of the fatty acid, palmitate [a measure of adipose DNL (f_DNL)], were assessed using an 8 week incorporation of deuterium into lipids (glycerol and palmitate moieties of TGs) in subcutaneous abdominal

SUBMITTER: White UA 

PROVIDER: S-EPMC6121936 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature