Circulating HDL levels control hypothalamic astrogliosis via apoA-I.

ABSTRACT: Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced neuronal injury triggers microgliosis and astrocytosis, conditions which ultimately may induce functional impairment of hypothalamic circuits governing feeding behavior, systemic metabolism, and body weight. Epidemiological data indicate that low circulating HDL levels, besides conveying cardiovascular risk, also correlate strongly with obesity. We simulated that condition by using a genetic loss of function mouse model (apoA-I^-/-) with markedly reduced HDL levels to investigate whether HDL may directly modulate hypothalamic inflammat

SUBMITTER: Gotz A 

PROVIDER: S-EPMC6121940 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature