Impaired Autophagy in Intestinal Epithelial Cells Alters Gut Microbiota and Host Immune Responses.

ABSTRACT: Establishing and maintaining beneficial interactions between the host and associated gut microbiota are pivotal requirements for host health. Autophagy is an important catabolic recycling pathway that degrades long-lived proteins and some organelles by lysosome to maintain cellular homeostasis. Although impaired autophagy is thought to be closely correlated with Crohn's disease (CD), the functional role of autophagy in the maintenance of gut microbiota is poorly understood. As autophagy-related 5 (Atg5) is a key gene associated with the extension of the phagophoric membrane in autophagic vesicles, we established a gut-specific Atg5 knockout mouse model, and we found that the disruption of autophagic flux in the intenstinal epithelium cells dramatically altered the composition

SUBMITTER: Yang L 

PROVIDER: S-EPMC6121970 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature