Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells.

ABSTRACT: Tumorigenesis is commonly known as a complicated process, in which reactive oxygen species (ROS) plays a critical role to involve in signal transduction, metabolism, cell proliferation and differentiation. Previously, ribosomal protein L10 (RPL10) was suggested to possess extra-ribosomal functions in pancreatic cancer cells in addition to being proposed as a tumor suppressor or transcription co-regulator. To better understand the relationship between RPL10 and tumorigenic potential in pancreatic cancer cells, chromatin immunoprecipitation sequencing reveals that RPL10 is unlikely to be a transcription factor without a specific binding motif for gene transcription. Additionally, transcriptome analysis indicates that RPL10 could regulate the expression of proteins related to ROS production.

SUBMITTER: Yang J 

PROVIDER: S-EPMC6122146 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature