Dataset Information

Adenovirus associated with acute diarrhea: a case-control study.

ABSTRACT:

Background

Diarrhea is a major source of morbidity and mortality among young children in low-income and middle-income countries. Human adenoviruses (HAdV), particular HAdV species F (40, 41) has been recognized as important causal pathogens, however limited data exist on molecular epidemiology of other HAdV associated with acute gastroenteritis.

Methods

In the present preliminary study, we performed a case-control study involving 273 children who presented diarrheal disease and 361 healthy children matched control in Children's hospital of Hebei Province (China) to investigate the relationship between non-enteric HAdV and diarrhea. HAdV were detected and quantified using quantitative real-time PCR (qPCR) and serotyped by sequencing and phylogenetic analysis. Odds ratio (OR) was used to assess the risk factor of HAdV.

Results

HAdV were detected in 79 (28.94%) of 273 children with diarrhea including 7 different serotypes (HAdV 40, 41, 3, 2,1,5 and 57) with serotypes 40, 41 and 3 being the most dominant and in 26 (7.20%) of 361 healthy children containing 9 serotypes (HAdV 40, 41, 3, 2,1,5,57,6 and 31). A majority (91.14%) of HAdV positives occurred in diarrhea children and 65.38% in controls< 3 years of age. No significant difference in the viral load was found between case and control groups or between Ad41-positive patients and healthy controls. In addition to HAdV 40 and 41, HAdV 3 was also associated with diarrhea (OR = 17.301, adjusted OR = 9.205, p < 0.001).

Conclusions

Our results demonstrate a high diversity of HAdV present among diarrhea and healthy children and implicate that non-enteric HAdV3 may lead to diarrhea.

SUBMITTER: Qiu FZ

PROVIDER: S-EPMC6122197 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Adenovirus associated with acute diarrhea: a case-control study.

Qiu Fang-Zhou FZ Shen Xin-Xin XX Li Gui-Xia GX Zhao Li L Chen Chen C Duan Su-Xia SX Guo Jing-Yun JY Zhao Meng-Chuan MC Yan Teng-Fei TF Qi Ju-Ju JJ Wang Le L Feng Zhi-Shan ZS Ma Xue-Jun XJ

BMC infectious diseases 20180903 1

<h4>Background</h4>Diarrhea is a major source of morbidity and mortality among young children in low-income and middle-income countries. Human adenoviruses (HAdV), particular HAdV species F (40, 41) has been recognized as important causal pathogens, however limited data exist on molecular epidemiology of other HAdV associated with acute gastroenteritis.<h4>Methods</h4>In the present preliminary study, we performed a case-control study involving 273 children who presented diarrheal disease and 36 ...[more]

PMID: 30176819

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Dataset Information

Adenovirus associated with acute diarrhea: a case-control study.

Background

Methods

Results

Conclusions

Publications

Adenovirus associated with acute diarrhea: a case-control study.

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