Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells.

ABSTRACT: The epithelial-mesenchymal transition-inducing transcription factor Snail contributes to tumor progression in different malignancies. In the present study, we used a transcriptomics approach to elucidate the mechanism of Snail-mediated tumor growth promotion in a Kras^LSL-G12D/+;p53^fl/fl mouse model of lung adenocarcinoma. We discovered that Snail mediated the downregulation of the imprinted Dlk1-Dio3 locus, a complex genomic region containing protein-coding genes and non-coding RNAs that has been linked to tumor malignancy in lung cancer patients. The Dlk1-Dio3 locus repression mediated by Snail was found to occur specifically in several populations of tumor-infiltrating immune cells. It could be reproduced in primary splenocytes upon ex vivo culture wit

SUBMITTER: Groeneveld S 

PROVIDER: S-EPMC6122344 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature