XCT inhibition sensitizes tumors to γ-radiation via glutathione reduction.

ABSTRACT: About 3 million US cancer patients and 1.7 million EU cancer patients received multiple doses of radiation therapy (RT) in 2012, with treatment duration limited by normal adjacent tissue damage. Tumor-specific sensitization could allow treatment with lower radiation doses, reducing normal tissue damage. This is a longstanding, largely unrealized therapeutic goal. The cystine:glutamate exchanger xCT is expressed on poor prognosis subsets of most solid tumors, but not on most normal cells. xCT provides cells with environmental cystine for enhanced glutathione synthesis. Glutathione is used to control reactive oxygen species (ROS), which are therapeutic effectors of RT. We tested whether xCT inhibition would sensitize xCT⁺ tumor cells to ionizing radiation. We found that pretreatme

SUBMITTER: Cobler L 

PROVIDER: S-EPMC6122354 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature