Discovering lncRNA mediated sponge interactions in breast cancer molecular subtypes.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs (ceRNAs) or as sponges. Previous studies identified lncRNA-mediated sponge interactions in various cancers including the breast cancer. However, breast cancer subtypes are quite distinct in terms of their molecular profiles; therefore, ceRNAs are expected to be subtype-specific as well.

Results

To find lncRNA-mediated ceRNA interactions in breast cancer subtypes, we develop an integrative approach. We conduct partial correlation analysis and kernel independence tests on patient gene expression profiles and further refine the candidate interactions with miRNA target information. We find that although there are spong

SUBMITTER: Olgun G 

PROVIDER: S-EPMC6122485 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature