African swine fever virus does not express viral microRNAs in experimentally infected pigs.

ABSTRACT:

Background

African swine fever virus (ASFV) is the etiological agent of African swine fever (ASF), a re-expanding devastating and highly lethal hemorrhagic viral disease. microRNAs (miRNAs) are a new class of small non-coding RNAs that regulate gene expression post-transcriptionally. The discovery of virus specific miRNAs has increased both in number and importance in the past few years. We have recently described the differential expression of several porcine miRNAs during in vivo infection with attenuated and virulent ASFV strains. Here, we have extended these studies trying to identify the presence of viral miRNAs encoded by ASFV in an in vivo infection in pigs.

Results

Sixteen small RNA libraries were analyzed from spleen and submandibular lymph nodes obtained from eight

SUBMITTER: Nunez-Hernandez F 

PROVIDER: S-EPMC6122539 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature