Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice.

ABSTRACT:

Background

Depression is one of the most common mental disorders characterized mainly by low mood and loss of interest or pleasure. About a third of patients with depression do not respond to classic antidepressant treatments. Recent evidence suggests that Mrp8/14 (myeloid-related protein 8/14) plays a crucial role in cognitive dysfunction and neuroinflammatory diseases, yet its role in mood regulation remains largely uninvestigated. In the present work, we explored the potential role of Mrp8/14 in the progression of depression.

Methods

After 4 weeks of chronic unpredictable mild stress (CUMS), depressive-like symptoms and Mrp8/14 were determined. To verify the effects of Mrp8/14 on depressive-like behaviors, the inhibitor TAK-242 and recombinant Mrp8/14 were used. Furthermo

SUBMITTER: Gong H 

PROVIDER: S-EPMC6122683 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature