Regional heterogeneity in response of airway epithelial cells to cigarette smoke.

ABSTRACT:

Background

Cigarette smoke (CS) exposure causes an abnormal inflammatory response, which can result in chronic obstructive pulmonary disease (COPD). Previous studies show that this disorder predominantly occurs in peripheral or small-airway areas, whereas the same condition has not been identified in the larger airways during the course of COPD. However, the different biochemical and genetic alterations occurring in response to CS exposure among airway epithelial cells from different sites in the lungs have not been fully investigated.

Methods

Human small airway epithelial cells (SAECs) and normal human bronchial epithelial cells (NHBEs) were exposed to CS extract (CSE), and microarray analysis was used to determine gene- and protein-expression profiles and identify alterati

SUBMITTER: Baskoro H 

PROVIDER: S-EPMC6122713 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature