Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression.

ABSTRACT:

Background

Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DNA methylation at the promoter CpG island. Few studies have explored the influence of genetic variation across the gene on DNA methylation, and their combined association with depression risk. The aim of this study was to determine whether genetic variation in the SLC6A4 gene influences promoter DNA methylation, and whether these are associated with depression status.

Method

The ESPRIT study involves a community-based population of older individuals (> 65 years of age). Major depressive dis

SUBMITTER: Lam D 

PROVIDER: S-EPMC6122720 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature