"Low-" versus "high"-frequency oscillation and right ventricular function in ARDS. A randomized crossover study.

ABSTRACT:

Background

Recent, large trials of high-frequency oscillation (HFO) versus conventional ventilation (CV) in acute respiratory distress syndrome (ARDS) reported negative results. This could be explained by an HFO-induced right ventricular (RV) dysfunction/failure due to high intrathoracic pressures and hypercapnia. We hypothesized that HFO strategies aimed at averting/attenuating hypercapnia, such as "low-frequency" (i.e., 4 Hz) HFO and 4-Hz HFO with tracheal-gas insufflation (HFO-TGI), may result in an improved RV function relative to "high-frequency" (i.e., 7 Hz) HFO (which may promote hypercapnia) and similar RV function relative to lung protective CV.

Methods

We studied 17 patients with moderate-to-severe ARDS [PaO₂-to-inspiratory O₂ fraction ratio (

SUBMITTER: Mentzelopoulos SD 

PROVIDER: S-EPMC6122746 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature