Anti-acid therapy in idiopathic pulmonary fibrosis: insights from the INPULSIS® trials.

ABSTRACT:

Background

The benefits and risks of anti-acid medication in patients with idiopathic pulmonary fibrosis (IPF) remain a topic of debate. We investigated whether use of anti-acid medication at baseline was associated with differences in the natural course of disease or influenced the treatment effect of nintedanib in patients with IPF.

Methods

Post-hoc analyses of outcomes in patients receiving versus not receiving anti-acid medication (proton pump or histamine-2 receptor inhibitor) at baseline using pooled data from the two Phase III randomized placebo-controlled INPULSIS® trials of nintedanib in patients with IPF.

Results

At baseline, 406 patients were receiving anti-acid medication (244 nintedanib; 162 placebo) and 655 were not (394 nintedanib; 261 placebo). In an a

SUBMITTER: Costabel U 

PROVIDER: S-EPMC6122773 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature