Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors.

ABSTRACT:

Background

With the emergence of new influenza virus strains that are resistant to current inhibitors such as oseltamivir (anti-neuraminidase (NA)) and amantadine (anti-M2 proton channel), influenza A viruses continue to be a serious threat to the public health worldwide. With this in view, there is a persistent need for the development of broader and more effective vaccines and therapeutics. Identification of broadly neutralizing antibodies (bNAbs) that recognize relatively invariant structures ‎on influenza haemagglutinin (HA) stem has invigorated efforts to develop universal influenza vaccines.

Aim

The current computational study is designed to identify potential flavonoid inhibitors that bind to the contact epitopes of HA stem that are targeted by broadly neutralizing an

SUBMITTER: Mathew S 

PROVIDER: S-EPMC6122827 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature