Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117.

ABSTRACT: A clinical trial was performed to evaluate 3BNC117, a potent anti-HIV-1 antibody, in infected individuals during suppressive antiretroviral therapy and subsequent analytical treatment interruption (ATI). The circulating reservoir was evaluated by quantitative and qualitative viral outgrowth assay (Q²VOA) at entry and after 6 mo. There were no significant quantitative changes in the size of the reservoir before ATI, and the composition of circulating reservoir clones varied in a manner that did not correlate with 3BNC117 sensitivity. 3BNC117 binding site amino acid variants found in rebound viruses preexisted in the latent reservoir. However, only 3 of 217 rebound viruses were identical to 868 latent viruses isolated by Q²VOA and near full-length sequencing. Instead, 6

SUBMITTER: Cohen YZ 

PROVIDER: S-EPMC6122972 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature