Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau.

ABSTRACT: Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells. We show that a RiboTag translational profiling approach can bypass biases due to cellular enrichment/cell sorting. Using this approach in models of amyloidosis, tauopathy, and aging, we revealed a common set of alterations and identified a central APOE-driven network that converged on CCL3 and CCL4 across all conditions. Notably, aged females demonstrated a significant exacerbation of many of these shared transcripts in this APOE network, revealing a potential mechanism for increased AD susceptibility in females. This study has broad implications for microglial transcriptomic approaches and provides new insight

SUBMITTER: Kang SS 

PROVIDER: S-EPMC6122978 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature