Ontology highlight
ABSTRACT:
SUBMITTER: Kang SS
PROVIDER: S-EPMC6122978 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20180806 9
Alzheimer's disease (AD) is an age-associated neurodegenerative disease characterized by amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells. We show that a RiboTag translational profiling approach can bypass biases due to cellular enrichment/cell sorting. Using this approach in models of amyloidosis, tauopathy, and aging, we revealed a common set of alterations and identified a central APOE-driven network that converged on CCL3 and CCL4 across all conditi ...[more]