Failure of monotherapy in clinical practice in patients with type 2 diabetes: The Korean National Diabetes Program.

ABSTRACT:

Aims/introduction

We investigated the failure of monotherapy in patients with type 2 diabetes mellitus in real practice settings.

Materials and methods

The Korean National Diabetes Program was a prospective, multicenter observational cohort study of type 2 diabetes mellitus patients in Korea. Of the 3,950 patients enrolled in the study, we studied 998 who were continuously maintained on monotherapy for at least 90 days at six participating centers. To balance the baseline characteristics of patients in each group, we used propensity matching at a 1:1 ratio (metformin vs sulfonylureas) and 4:1 ratio (metformin vs meglitinides and metformin vs alpha-glucosidase inhibitors [aGIs]). The hazard ratios (HRs) of treatments (compared with metformin) were determined by Cox's proporti

SUBMITTER: Jeon JY 

PROVIDER: S-EPMC6123024 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature