Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes.

ABSTRACT:

Aims/introduction

Variants on chromosome 1p13 have been associated with coronary artery disease and acute myocardial infarction risk in different ethnic groups. The present study aimed to investigate the association between 1p13 polymorphisms and the development of peripheral artery disease (PAD) in a Chinese population with type 2 diabetes mellitus.

Materials and methods

1p13 polymorphisms, rs599839, rs646776 and rs12740374, were assessed in a cohort of 882 type 2 diabetes mellitus patients including 440 type 2 diabetes mellitus patients with PAD (DM + PAD group) and 442 patients without PAD (DM group). Genotyping was carried out using TaqMan assay.

Results

Compared with the DM group, the frequencies of the minor G allele of both rs599839 and rs646776 and the minor T

SUBMITTER: Qin J 

PROVIDER: S-EPMC6123029 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature