Insulin deficiency with and without glucagon: A comparative study between total pancreatectomy and type 1 diabetes.

ABSTRACT:

Aims/introduction

Patients with a total pancreatectomy and type 1 diabetes are similar in regard to absolute insulin deficiency, but different in regard to glucagon, providing a unique opportunity to study the contribution of glucagon to glucose metabolism in an insulin-dependent state. The aim of the present study was to investigate the contribution of glucagon to glucose homeostasis in complete insulin deficiency in vivo.

Methods

A total of 38 individuals with a complete lack of endogenous insulin (fasting C-peptide <0.0066 nmol/L) and whose glycemic control was optimized with an insulin pump during hospitalization were retrospectively studied. The basal insulin requirement, time-to-time adjustment of the basal insulin infusion rate, prandial insulin requirement and fastin

SUBMITTER: Niwano F 

PROVIDER: S-EPMC6123030 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature