Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer.

ABSTRACT:

Objective

We aimed to investigate the association of the frequency of three single-nucleotide polymorphisms [glucose transporter isoform 1 (GLUT1) reference single-nucleotide polymorphism (rs) 710218, hypoxia-inducible factor 1 alpha (HIF1α) rs11549465, and T-box transcription factor protein 21 (TBX21) rs17250932], which have been proved to be related with various benign and malignant diseases, with the development of laryngeal cancer and its size and grade.

Methods

In this study, we included 35 patients with laryngeal cancer and 35 volunteers at least 30 years old who had smoked for at least 20 years. DNA was obtained from the blood samples of the participants using an isolation kit. Then, polymorphisms for both the groups were determined using real-time polymerase chain re

SUBMITTER: Uslu C 

PROVIDER: S-EPMC6123110 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature