A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease.

ABSTRACT:

Background

Contralateral brain structures represent a unique, within-patient reference element for disease, and asymmetries can provide a personalized measure of the accumulation of past disease processes. Neuroanatomical shape asymmetries have recently been associated with the progression of Alzheimer's disease (AD), but the biological basis of asymmetric brain changes in AD remains unknown.

Methods

We investigated genetic influences on brain asymmetry by identifying associations between magnetic resonance imaging-derived measures of asymmetry and candidate single nucleotide polymorphisms (SNPs) that have previously been identified in genome-wide association studies for AD diagnosis and for brain subcortical volumes. For analyzing longitudinal neuroimaging data (1241 indivi

SUBMITTER: Wachinger C 

PROVIDER: S-EPMC6123250 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature