Mechanisms and mitigating factors for venous thromboembolism in chronic kidney disease: the REGARDS study.

ABSTRACT: Essentials Chronic kidney disease (CKD) is associated with procoagulant and inflammatory biomarkers. We studied the association of CKD and venous thromboembolism (VTE) in a case-cohort study. Factor VIII, D-dimer and C-reactive protein appeared to explain the association of CKD and VTE. Statin use was protective against VTE in those with and without CKD.

Summary

Background Chronic kidney disease (CKD) is associated with venous thromboembolism (VTE) risk via unknown mechanisms. Whether factors associated with reduced VTE risk in the general population might also be associated with reduced VTE risk in CKD patients is unknown. Objectives To determine whether thrombosis biomarkers attenuate VTE risk, and whether factors associated with reduced VTE risk are similarly effective in CKD pat

SUBMITTER: Cheung KL 

PROVIDER: S-EPMC6123283 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature