Physiological Response of Corynebacterium glutamicum to Increasingly Nutrient-Rich Growth Conditions.

ABSTRACT: To ensure economic competitiveness, bioprocesses should achieve maximum productivities enabled by high growth rates (μ) and equally high substrate consumption rates (q_S) as a prerequisite of sufficient carbon-to-product conversion. Both traits were investigated and improved via bioprocess engineering approaches studying the industrial work horse Corynebacterium glutamicum. Standard minimal medium CGXII with glucose as sole carbon source was supplemented with complex brain-heart-infusion (BHI) or amino acid (AA) cocktails. Maximum μ of 0.67 h^-1 was exclusively observed in 37 g BHI L^-1 whereas only minor growth stimulation was found after AA supplementation (μ = 0.468 h^-1). Increasing glucose consumption rates (q_Glc) were solely o

SUBMITTER: Graf M 

PROVIDER: S-EPMC6123352 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature