Continuous infusion of PTH_1-34 delayed fracture healing in mice.

ABSTRACT: Hyperparathyroidism, which is increased parathyroid hormone (PTH) levels in the blood, could cause delayed or non-union of bone fractures. But, no study has yet demonstrated the effects of excess continuous PTH exposure, such as that seen in hyperparathyroidism, for fracture healing. Continuous human PTH_1-34 (teriparatide) infusion using an osmotic pump was performed for stabilized tibial fractures in eight-week-old male mice to determine the relative bone healing process compared with saline treatment. Radiographs and micro-computed tomography showed delayed but increased calcified callus formation in the continuous PTH_1-34 infusion group compared with the controls. Histology and quantitative histomorphometry confirmed that continuous PTH_1-34 treatment sig

SUBMITTER: Yukata K 

PROVIDER: S-EPMC6123430 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature