New Variant of Multidrug-Resistant <i>Salmonella enterica</i> Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.

ABSTRACT: Nontyphoidal Salmonella (NTS), particularly Salmonella enterica serovar Typhimurium, is among the leading etiologic agents of bacterial enterocolitis globally and a well-characterized cause of invasive disease (iNTS) in sub-Saharan Africa. In contrast, S Typhimurium is poorly defined in Southeast Asia, a known hot spot for zoonotic disease with a recently described burden of iNTS disease. Here, we aimed to add insight into the epidemiology and potential impact of zoonotic transfer and antimicrobial resistance (AMR) in S Typhimurium associated with iNTS and enterocolitis in Vietnam. We performed whole-genome sequencing and phylogenetic reconstruction on 85 human (enterocolitis, carriage, and iNTS) and 113 animal S Typhimurium isolates isolated in Vietnam.

SUBMITTER: Mather AE 

PROVIDER: S-EPMC6123440 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature