Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression.

ABSTRACT: Risk-taking behaviour is an important component of several psychiatric disorders, including attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two genetic loci have been associated with self-reported risk taking and significant genetic overlap with psychiatric disorders was identified within a subsample of UK Biobank. Using the white British participants of the full UK Biobank cohort (n = 83,677 risk takers versus 244,662 controls) for our primary analysis, we conducted a genome-wide association study of self-reported risk-taking behaviour. In secondary analyses, we assessed sex-specific effects, trans-ethnic heterogeneity and genetic overlap with psychiatric traits. We also investigated the impact of risk-taking-associated SNPs on both gene expressio

SUBMITTER: Strawbridge RJ 

PROVIDER: S-EPMC6123450 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature