Suppression of m⁶A reader Ythdf2 promotes hematopoietic stem cell expansion.

ABSTRACT: Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB) holds great promise for treating a broad spectrum of hematological disorders including cancer. However, the limited number of HSCs in a single hUCB unit restricts its widespread use. Although extensive efforts have led to multiple methods for ex vivo expansion of human HSCs by targeting single molecules or pathways, it remains unknown whether it is possible to simultaneously manipulate the large number of targets essential for stem cell self-renewal. Recent studies indicate that N⁶-methyladenosine (m⁶A) modulates the expression of a group of mRNAs critical for stem cell-fate determination by influencing their stability. Among several m⁶A readers, YTHDF2 is recognized a

SUBMITTER: Li Z 

PROVIDER: S-EPMC6123498 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature