Feeling left out: depressed adolescents may atypically recruit emotional salience and regulation networks during social exclusion.

ABSTRACT: Depression is associated with negative attention and attribution biases and maladaptive emotion responsivity and regulation, which adversely impact self-evaluations and interpersonal relationships. Using functional magnetic resonance imaging, we investigated the neural substrates of these impairments. We compared neural activity recruited by 126 clinically depressed and healthy adolescents (ages 11-17 years) during social exclusion (Exclusion > Inclusion) using Cyberball. Results revealed significant interaction effects within left anterior insula (AI)/inferior frontal gyrus and left middle temporal gyrus. Insula hyperresponsivity was associated with peer exclusion for depressed adolescents but peer inclusion for healthy adolescents. In additional, healthy adolescents recruited greater lat

SUBMITTER: Jankowski KF 

PROVIDER: S-EPMC6123522 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature