Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis.

ABSTRACT: Nanosurfaces have improved clinical osseointegration by increasing bone/implant contact. Neovascularization is considered an essential prerequisite to osteogenesis, but no previous reports to our knowledge have examined the effect of surface topography on the spatio-temporal pattern of neovascularization during peri-implant healing. We have developed a cranial window model to study peri-implant healing intravitally over clinically relevant time scales as a function of implant topography. Quantitative intravital confocal imaging reveals that changing the topography (but not chemical composition) of an implant profoundly affects the pattern of peri-implant neovascularization. New vessels develop proximal to the implant and the vascular network matures sooner in the presence of an implant nan

SUBMITTER: Khosravi N 

PROVIDER: S-EPMC6123776 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature