Kir4.1 channels in NG2-glia play a role in development, potassium signaling, and ischemia-related myelin loss.

ABSTRACT: The contribution of the inwardly rectifying K⁺ channel subtype Kir4.1 has been focused mainly on astrocytes, where they play important roles in the maintenance of resting membrane potential, extracellular K⁺ uptake, and facilitation of glutamate uptake in the central nervous system. Here, we report the role of Kir4.1 channels in NG2-glia during brain development, potassium signaling, and in an ischemic stroke disease model. Kir4.1 channels are widely expressed in NG2-glia during brain development. In the adult mouse hippocampus, Kir4.1 channels in NG2-glia constitute more than 80% of K⁺ channels inward currents. This large portion of Kir4.1 channel currents exhibits a deficit in NG2-glia as an initial response in a transient ischemic mouse model. Further ev

SUBMITTER: Song F 

PROVIDER: S-EPMC6123808 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature