Generation of a C57BL/6 MYC-Driven Mouse Model and Cell Line of Prostate Cancer.

ABSTRACT:

Introduction

Transgenic mouse modeling is a favorable tool to reflect human prostate tumorigenesis and interactions between prostate cancer and the microenvironment. The use of GEMMs and derived cell lines represent powerful tools to study prostate cancer initiation and progression with an associated tumor microenvironment. Notably, such models provide the capacity for rapid preclinical therapy studies including immune therapies for prostate cancer treatment.

Methods

Backcrossing FVB Hi-MYC mice with C57BL/6N mice, we established a Hi-MYC transgenic mouse model on a C57BL/6 background (B6MYC). In addition, using a conditional reprogramming method, a novel C57BL/6 MYC driven prostate adenocarcinoma cell line was generated.

Results

Our results demonstrate that disease p

SUBMITTER: Ellis L 

PROVIDER: S-EPMC6123824 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature