Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study.

ABSTRACT:

Objective

To assess whether statin treatment is associated with a reduction in atherosclerotic cardiovascular disease (CVD) and mortality in old and very old adults with and without diabetes.

Design

Retrospective cohort study.

Setting

Database of the Catalan primary care system (SIDIAP), Spain, 2006-15.

Participants

46 864 people aged 75 years or more without clinically recognised atherosclerotic CVD. Participants were stratified by presence of type 2 diabetes mellitus and as statin non-users or new users.

Main outcome measures

Incidences of atherosclerotic CVD and all cause mortality compared using Cox proportional hazards modelling, adjusted by the propensity score of statin treatment. The relation of age with the effect of statins was assessed using b

SUBMITTER: Ramos R 

PROVIDER: S-EPMC6123838 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature