Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration.

ABSTRACT: Microglia are brain immune cells that constantly survey their environment to maintain homeostasis. Enhanced microglial reactivity and proliferation are typical hallmarks of neurodegenerative diseases. Whether specific disease-linked microglial subsets exist during the entire course of neurodegeneration, including the recovery phase, is currently unclear. Taking a single-cell RNA-sequencing approach in a susceptibility gene-free model of nerve injury, we identified a microglial subpopulation that upon acute neurodegeneration shares a conserved gene regulatory profile compared to previously reported chronic and destructive neurodegeneration transgenic mouse models. Our data also revealed rapid shifts in gene regulation that defined microglial subsets at peak and resolution of neurodegenerati

SUBMITTER: Tay TL 

PROVIDER: S-EPMC6123921 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature