NOTCH3 expression is linked to breast cancer seeding and distant metastasis.

ABSTRACT:

Background

Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs. NOTCH developmental signaling plays a critical role in promoting epithelial-to-mesenchymal transition, tumor stemness, and metastasis. Although all four NOTCH receptors show oncogenic properties, the unique role of each of these receptors in the sequential stepwise events that typify the invasion-metastasis cascade remains elusive.

Methods

We have established metastatic xenografts expressing high endogenous levels of NOTCH3 using estrogen receptor alpha-positive (ERα⁺) MCF-7 breast cancer cells with constitutive active Raf-1/mitogen-associated pr

SUBMITTER: Leontovich AA 

PROVIDER: S-EPMC6123953 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature