Novel magnetic resonance technique for characterizing mesoscale structure of trabecular bone.

ABSTRACT: Osteoporosis, characterized by increased fracture risk and bone fragility, impacts millions of adults worldwide, but effective, non-invasive and easily accessible diagnostic tests of the disease remain elusive. We present a magnetic resonance (MR) technique that overcomes the motion limitations of traditional MR imaging to acquire high-resolution frequency-domain data to characterize the texture of biological tissues. This technique does not involve obtaining full two-dimensional or three-dimensional images, but can probe scales down to the order of 40 μm and in particular uncover structural information in trabecular bone. Using micro-computed tomography data of vertebral trabecular bone, we computationally validate this MR technique by simulating MR measurements of a 'ratio metric' determ

SUBMITTER: Nguyen C 

PROVIDER: S-EPMC6124118 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature