The mutational landscape of recurrent versus nonrecurrent human papillomavirus-related oropharyngeal cancer.

ABSTRACT:

Background

Human papillomavirus-related (HPV-related) oropharyngeal squamous cell carcinomas (OPSCCs) have an excellent response rate to platinum-based chemoradiotherapy. Genomic differences between primary HPV-related OPSCCs that do or do not recur are unknown. Furthermore, it is unclear if HPV-related OPSCCs that recur share a genomic landscape with HPV-negative head and neck cancers (HNCs).

Methods

We utilized whole exome sequencing to analyze somatic nucleotide (SNVs) and copy number variants (CNVs) among a unique set of 51 primary HPV-related OPSCCs, including 35 that did not recur and 16 that recurred. We evaluated 12 metachronous recurrent OPSCCs (7 with paired primary OPSCCs) and 33 primary HPV-unrelated oral cavity and OPSCCs.

Results

KMT2D was the most frequ

SUBMITTER: Harbison RA 

PROVIDER: S-EPMC6124437 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature