The total alkaloids from Coptis chinensis Franch improve cognitive deficits in type 2 diabetic rats.

ABSTRACT:

Background

Coptis chinensis Franch is extensively used in traditional Chinese medicine to treat diabetes and dementia. Alkaloids are the main active ingredients of C. chinensis.

Purpose

This study was designed to probe the effects and possible mechanisms of the total alkaloids from C. chinensis (TAC) on cognitive deficits in type 2 diabetic rats.

Methods

Cognitive deficits were induced in rats by streptozotocin and high glucose/high fat diet. After treatment with TAC (80, 120, and 180 mg/kg) for 24 weeks, the behavioral parameters of each rat were assessed by Morris water maze and Y-maze tests. The indexes of glucose and lipid metabolism, pathological changes of brain tissue, and the phosphorylation levels of insulin signaling related proteins wer

SUBMITTER: Li JC 

PROVIDER: S-EPMC6124445 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature