Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis.

ABSTRACT:

Objective

To explore the relationship between single-nucleotide polymorphisms (SNPs) in one of the long noncoding RNA (lncRNA), cancer susceptibility candidate 8 (CASC8) gene and the risk of cancer.

Materials and methods

A meta-analysis was conducted to summarize the relationship between common SNPs (rs10505477 and rs7837328) in the lncRNA CASC8 gene and the risk of cancer. The relevant references were retrieved from several authoritative databases. Rigorous inclusion and exclusion criteria were adopted to ensure the credibility of the results. The fixed effects or random effects model was used to calculate the OR and 95% CI. We tested for publication bias.

Results

Fifteen articles containing 20 datasets (24,504 cases and 22,969 controls) were finally in

SUBMITTER: Cui Z 

PROVIDER: S-EPMC6124472 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature