HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways.

ABSTRACT: The genomic integration of HIV into cells results in long-term persistence of virally infected cell populations. This integration event acts as a heritable mark that can be tracked to monitor infected cells that persist over time. Previous reports have documented clonal expansion in people and have linked them to proto-oncogenes; however, their significance or contribution to the latent reservoir has remained unclear. Here, we demonstrate that a directed pattern of clonal expansion occurs in vivo, specifically in gene pathways important for viral replication and persistence. These biological processes include cellular division, transcriptional regulation, RNA processing, and posttranslational modification pathways. This indicates preferential expansion when integration events occur within

SUBMITTER: Haworth KG 

PROVIDER: S-EPMC6124524 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature