Circulating RIPK3 levels are associated with mortality and organ failure during critical illness.

ABSTRACT:

Background

Necroptosis is a form of programmed necrotic cell death that is rapidly emerging as an important pathophysiological pathway in numerous disease states. Necroptosis is dependent on receptor-interacting protein kinase 3 (RIPK3), a protein shown to play an important role in experimental models of critical illness. However, there is limited clinical evidence regarding the role of extracellular RIPK3 in human critical illness.

Methods

Plasma RIPK3 levels were measured in 953 patients prospectively enrolled in 5 ongoing intensive care unit (ICU) cohorts in both the USA and Korea. RIPK3 concentrations among groups were compared using prospectively collected phenotypic and outcomes data.

Results

In all 5 cohorts, extracellular RIPK3 levels in the plasma were higher

SUBMITTER: Ma KC 

PROVIDER: S-EPMC6124535 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature