Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children.

ABSTRACT:

Background

It is often assumed that selection (including participation and dropout) does not represent an important source of bias in genetic studies. However, there is little evidence to date on the effect of genetic factors on participation.

Methods

Using data on mothers (N = 7486) and children (N = 7508) from the Avon Longitudinal Study of Parents and Children, we: (i) examined the association of polygenic risk scores for a range of sociodemographic and lifestyle characteristics and health conditions related to continued participation; (ii) investigated whether associations of polygenic scores with body mass index (BMI; derived from self-reported weight and height) and self-reported smoking differed in the largest sample with genetic data and a subsample who participated

SUBMITTER: Taylor AE 

PROVIDER: S-EPMC6124613 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature