Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts.

ABSTRACT:

Background

Observational studies have shown that tobacco and alcohol use co-occur, but it is not clear whether this relationship is causal.

Methods

Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK Biobank, we used observational methods to test the hypothesis that smoking heaviness increases alcohol consumption. Mendelian randomization (MR) analyses were then used to test the causal relationship between smoking heaviness and alcohol consumption using 55 967 smokers from four European studies [ALSPAC, The Nord-Trøndelag Health Study (HUNT), the Copenhagen General Population Study (CGPS) and UK Biobank]. MR analyses used rs1051730/rs16969968 as a genetic proxy for smoking heaviness.

Results

Observational results provided evidence of an

SUBMITTER: Taylor M 

PROVIDER: S-EPMC6124618 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature